Gelsolin activity controls efficient early HIV-1 infection
نویسندگان
چکیده
منابع مشابه
Construction of a Novel Virus That Targets HIV-1-Infected Cells and Controls HIV-1 Infection
We describe a recombinant vesicular stomatitis virus lacking its glycoprotein gene and expressing instead the HIV-1 receptor CD4 and a coreceptor, CXCR4. This virus was unable to infect normal cells but did infect, propagate on, and kill cells that were first infected with HIV-1 and therefore had the HIV membrane fusion protein on their surface. Killing of HIV-1-infected cells controlled HIV in...
متن کاملEvaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection
Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...
متن کاملDifferential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization
BACKGROUND HIV-1 in genital secretions may be opsonized by several molecules including complement components. Opsonized HIV-1 by complement enhances the infection of various mucosal target cells, such as dendritic cells (DC) and epithelial cells. RESULTS We herein evaluated the effect of HIV-1 complement opsonization on microbicide candidates' activity, by using three in vitro mucosal models:...
متن کاملThe dynamics of HIV-1 adaptation in early infection.
Human immunodeficiency virus type 1 (HIV-1) undergoes a severe population bottleneck during sexual transmission and yet adapts extremely rapidly to the earliest immune responses. The bottleneck has been inferred to typically consist of a single genome, and typically eight amino acid mutations in viral proteins spread to fixation by the end of the early chronic phase of infection in response to ...
متن کاملBeyond antiretroviral therapy: early interventions to control HIV-1 infection.
The HIV-1 reservoir is established very early after transmission when proviruses become integrated in the genome of long-lived immune cells. Three to 6 days after infection, intracellular HIV-1 DNA in CD4þ T cells and virions attached to antigen-presenting cells can be detected in regional draining lymph nodes [1]. The rapid dissemination of HIV-1 in humans corresponds to observations in nonhum...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Retrovirology
سال: 2013
ISSN: 1742-4690
DOI: 10.1186/1742-4690-10-39